Inicio > Matemáticas y ciencia > Biologia, ciencias de la vida > Ciencias de la vida: cuestiones generales > Genética (no médica) > Polymorphismen in einigen Genen, die mit Typ-1-Diabetes mellitus assoziiert sind
Polymorphismen in einigen Genen, die mit Typ-1-Diabetes mellitus assoziiert sind

Polymorphismen in einigen Genen, die mit Typ-1-Diabetes mellitus assoziiert sind

Ali Salim Al Shehmany

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Editorial:
KS OmniScriptum Publishing
Año de edición:
2025
Materia
Genética (no médica)
ISBN:
9786209422843
60,52 €
IVA incluido
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Typ-1-Diabetes (T1DM) ist eine Autoimmunerkrankung, die durch die Zerstörung der insulinproduzierenden β-Zellen der Bauchspeicheldrüse durch das Immunsystem gekennzeichnet ist. Dies führt bei T1DM-Patienten zu einer gestörten Regulierung des Blutzuckerspiegels. Die Zerstörung der β-Zellen der Langerhans-Inseln wird durch die Infiltration von dendritischen Zellen, Makrophagen und T-Lymphozyten verursacht. Normalerweise basieren Studien zur genetischen Suszeptibilität (Assoziation) auf der Bewertung der Rolle von Genotyp-Markern (typischerweise SNPs) für die Anfälligkeit für die betreffende Krankheit in einer Fall-Kontroll- oder familienbasierten Stichprobe. Viele Gene, die mit Typ-1-Diabetes mellitus assoziiert sind, CTLA-4, PTPN22, IL-10, IL-18, VIT-D-Rezeptor, gehören zu den häufig bestätigten T1DM-Suszeptibilitätsgenen.

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